HClO4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers-Reference-Cited by-同舟云学术

HClO4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers

Published:2019 Issue:43 Volume:17 Page:9430-9434
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tian You-Ping¹²³⁴,Gong Yi¹²³⁴,Hu Xiao-Si⁵⁶⁷⁸⁹,Yu Jin-Sheng⁵⁶⁷⁸⁹,Zhou Ying¹²³⁴,Zhou Jian⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. College of Pharmacy

2. Guizhou University of Traditional Chinese Medicine

3. Guiyang 550025

4. China

5. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

6. Shanghai Key Laboratory of Green Chemistry and Chemical Processes

7. School of Chemistry and Molecular Engineering

8. East China Normal University

9. Shanghai 200062

Abstract

A highly efficient metal-free catalytic aldol-type reaction of fluorinated enol silyl ethers and acetals/ketals toward functionalized fluoroalkyl ethers is developed by using less than 1.0 mol% HClO₄ (70 wt%, aq.).

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB02129A

Reference92 articles.

1. I. Ojima , Fluorine in Medicinal Chemistry and Chemical Biology , Blackwell Publishing Ltd , 2009

2. Fluorine in Pharmaceuticals: Looking Beyond Intuition

3. Fluorine in medicinal chemistry

4. Understanding organofluorine chemistry. An introduction to the C–F bond

5. The C–F bond as a conformational tool in organic and biological chemistry

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