VCD spectroscopy reveals that a water molecule determines the conformation of azithromycin in solution-Reference-Cited by-同舟云学术

VCD spectroscopy reveals that a water molecule determines the conformation of azithromycin in solution

Published:2021 Issue:33 Volume:57 Page:4031-4034
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Demarque Daniel P.¹²³⁴⁵^ORCID,Kemper Michael¹²³⁴⁵,Merten Christian¹²³⁴⁵^ORCID

Affiliation:

1. Ruhr-Universität Bochum

2. Organische Chemie 2

3. Stereochemistry and Chiroptical Spectroscopy

4. Universitätsstraße 150

5. 44801 Bochum

Abstract

Despite the large and flexible structure of azithromycin, VCD spectroscopy is sensitive to a single molecule of water incorporated in the hydrogen bonding network above the macrocycle.

Funder

Alexander von Humboldt-Stiftung

Deutsche Forschungsgemeinschaft

Boehringer Ingelheim Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC00932J

Reference39 articles.

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4. Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons

5. Application of electronic circular dichroism in configurational and conformational analysis of organic compounds

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