Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions-Reference-Cited by-同舟云学术

Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions

Published:2018 Issue:8 Volume:9 Page:2159-2167
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hubert Jonathan G.¹²³⁴⁵,Stepek Iain A.¹²³⁴⁵,Noda Hidetoshi⁶⁷⁸^ORCID,Bode Jeffrey W.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratorium für Organische Chemie

2. Department of Chemistry and Applied Biosciences

3. ETH Zürich

4. Zürich

5. Switzerland 8093

6. Institute of Microbial Chemistry (Bikaken)

7. Tokyo 141-0021

8. Japan

Abstract

A new thiadiazole-forming macrocyclization reaction enables the one-pot synthesis of cyclic β-peptide libraries from readily accessible building blocks without additional reagents.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC05057G

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1. How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets

2. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

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