Algorithm-driven activity-directed expansion of a series of antibacterial quinazolinones-Reference-Cited by-同舟云学术

Algorithm-driven activity-directed expansion of a series of antibacterial quinazolinones

Published:2022 Issue:48 Volume:20 Page:9672-9678
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Francis Daniel¹²,Farooque Sannia¹²,Meager Archie¹²,Derks Didi¹,Leggott Abbie¹²,Warriner Stuart¹²,O'Neill Alex J.²³,Nelson Adam¹²^ORCID

Affiliation:

1. School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK

2. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK

3. School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK

Abstract

Algorithms were harnessed in the design of arrays of photoredox-catalysed microscale reactions whose crude products were screened for antibacterial activity. The approach enabled expansion of a series of antibacterial agents.

Funder

University of Leeds

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01404A

Reference34 articles.

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