LC-MS-based metabolomics reveals the <i>in vivo</i> effect of Shegan Mahuang Decoction in an OVA-induced rat model of airway hyperresponsiveness-Reference-Cited by-同舟云学术

LC-MS-based metabolomics reveals the in vivo effect of Shegan Mahuang Decoction in an OVA-induced rat model of airway hyperresponsiveness

Published:2022 Issue:10 Volume:18 Page:957-966
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Han Yuqing¹²,Guo Wenjun¹²,Li Xingxing²,Xu Xiaohang¹²,Yang Jingxuan¹²,Xie Shengxu²,Liu Yue²,Zhang Hongming²,Wang Yang³^ORCID,Xu Yajuan²

Affiliation:

1. School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China

2. Key Laboratory of Medicinal Materials, Jilin Academy of Chinese Medicine Sciences, Changchun 130021, China

3. Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China

Abstract

This study reveals that the Shegan Mahuang Decoction (SMD) exerts an anti-asthma effect against OVA-induced airway AHR via comprehensively modulating the sphingolipid metabolism, arachidonic acid metabolism, and PPAR signaling pathways.

Funder

Natural Science Foundation of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MO/D2MO00216G

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