Integrative proteomics and metabolomics analysis reveals the toxicity of cationic liposomes to human normal hepatocyte cell line L02-Reference-Cited by-同舟云学术

Integrative proteomics and metabolomics analysis reveals the toxicity of cationic liposomes to human normal hepatocyte cell line L02

Published:2018 Issue:5 Volume:14 Page:362-372
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Yu Jing¹²³⁴⁵,Chen Jun¹²³⁴⁵,Zhao Hongxia⁶³⁷⁵,Gao Jie⁶³⁷⁵,Li Ying¹²³⁴⁵,Li Yang¹²³⁴⁵,Xue Jiyang¹⁸⁹¹⁰⁵,Dahan Arik¹¹⁶¹²¹³¹⁴,Sun Duxin¹⁵¹⁶¹⁷¹⁸¹⁹,Zhang Guoqing¹²³⁴⁵,Zhang Hai¹⁸⁹¹⁰⁵^ORCID

Affiliation:

1. Department of Pharmacy

2. Eastern Hepatobiliary Surgery Hospital

3. Second Military Medical University

4. Shanghai 200438

5. China

6. School of Pharmacy

7. Shanghai 200433

8. Shanghai First Maternity and Infant Hospital

9. Tongji University School of Medicine

10. Shanghai 201204

11. Department of Clinical Biochemistry and Pharmacology

12. Ben-Gurion University of the Negev

13. Beer-Sheva 84105

14. Israel

15. Department of Pharmaceutical Science

16. College of Pharmacy

17. University of Michigan

18. Ann Arbor

19. USA

Abstract

Changes in the expression of proteins and profiles of metabolites in L02 cells were investigated after exposure to CLs based on the iTRAQ and UHPLC-Q-TOF/MS, and proteomics data were coupled with metabolomics data to comprehensively assess the potential toxicity mechanisms of CLs.

Funder

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MO/C8MO00132D

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