Construction of azaspirocyclic skeletons mediated by the carbonyl of the Weinreb amide: formal total synthesis of (±)-cephalotaxine-Reference-Cited by-同舟云学术

Construction of azaspirocyclic skeletons mediated by the carbonyl of the Weinreb amide: formal total synthesis of (±)-cephalotaxine

Published:2022 Issue:9 Volume:20 Page:1879-1882
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Jianyin¹,Zhang Jian¹²^ORCID,Fan Yuxue¹,Ding Huili¹,Liu Tianfu¹,Li Shanshan¹,Jiang Minghua¹,Liu Lu¹

Affiliation:

1. School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, P. R. China

2. Key Laboratory of Chemistry and Quality for TCM of the College of Gansu Province, Lanzhou 730000, P. R. China

Abstract

A facile Stevens rearrangement of the Weinreb amide and the subsequent key steps mediated by the carbonyl of the Weinreb amide led to the construction of azaspirocyclic skeletons of some typical alkaloids.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02304G

Reference52 articles.

1. Homoharringtonine/Omacetaxine Mepesuccinate: The Long and Winding Road to Food and Drug Administration Approval

2. Subcutaneous omacetaxine mepesuccinate in patients with chronic myeloid leukemia in tyrosine kinase inhibitor-resistant patients: Review and perspectives

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4. An Efficient Total Synthesis of (±)-Stemonamine

5. Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide Using a Radical Cascade

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