Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines-Reference-Cited by-同舟云学术

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines

Published:2016 Issue:16 Volume:14 Page:3889-3905
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Patel Alpa¹²³⁴,Sharp Swee Y.⁵⁶⁷⁸⁴,Hall Katelan¹²³⁴,Lewis William¹²³⁴,Stevens Malcolm F. G.⁹²³⁴,Workman Paul⁵⁶⁷⁸⁴,Moody Christopher J.¹²³⁴

Affiliation:

1. School of Chemistry

2. University of Nottingham

3. Nottingham

4. UK

5. Cancer Research UK Cancer Therapeutics Unit

6. Division of Cancer Therapeutics

7. The Institute of Cancer Research

8. London

9. School of Pharmacy

Abstract

Fused imidazoles inhibit growth of human cancer cell lines, and the Hsp70 pathway in cells, and induce apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00471G

Reference41 articles.

1. Muscarine, imidaozle, oxazole and thiazole alkaloids

2. Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles

3. Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies

4. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

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