In vitro vascularization of tissue engineered constructs by non-viral delivery of pro-angiogenic genes

Author:

Moreira Helena R.12345ORCID,Raftery Rosanne M.678910,da Silva Lucília P.12345,Cerqueira Mariana T.12345,Reis Rui L.12345,Marques Alexandra P.12345,O'Brien Fergal J.678910

Affiliation:

1. 3B's Research Group

2. I3Bs – Research Institute on Biomaterials

3. Biodegradables and Biomimetics

4. Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine

5. University of Minho

6. Tissue Engineering Research Group

7. Dept. of Anatomy & Regenerative Medicine

8. Royal College of Surgeons in Ireland (RCSI)

9. Dublin

10. Ireland

Abstract

The angiogenic capacity of fibroblasts is maximized through the deliver of plasmids and release of angiogenic proteins. Consequentially, endothelial cells proliferate and organize, demonstrating the potential of the system where vascularization is required.

Funder

Horizon 2020 Framework Programme

Division of Human Resource Management

Health Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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