Harnessing subcellular-resolved organ distribution of cationic copolymer-functionalized fluorescent nanodiamonds for optimal delivery of active siRNA to a xenografted tumor in mice

Author:

Claveau Sandra12345,Kindermann Marek678910,Papine Alexandre111213,Díaz-Riascos Zamira V.1415161718ORCID,Délen Xavier11932021,Georges Patrick11932021,López-Alemany Roser2223242526ORCID,Tirado Òscar Martínez2223242526ORCID,Bertrand Jean-Rémi12732829,Abasolo Ibane1415161718ORCID,Cigler Petr678ORCID,Treussart François12345ORCID

Affiliation:

1. Université Paris-Saclay

2. ENS Paris-Saclay

3. CNRS

4. CentraleSupélec

5. LuMIn

6. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

7. 166 10 Prague

8. Czech Republic

9. Department of Chemical Engineering

10. University of Chemistry and Technology

11. IMSTAR S.A.

12. 75014 Paris

13. France

14. Drug Delivery & Targeting

15. Functional Validation & Preclinical Research (FVPR)

16. CIBBIM-Nanomedicine

17. Vall d'Hebron Institut de Recerca (VHIR)

18. Universitat Autònoma de Barcelona (UAB)

19. Institut d'Optique Graduate School

20. Laboratoire Charles Fabry

21. 91127 Palaiseau

22. Sarcoma Research Group

23. Oncobell Program

24. CIBERONC

25. Bellvitge Biomedical Research Institute (IDIBELL)

26. 08908 L'Hospitalet de Llobregat

27. Institut Gustave Roussy

28. Metabolic and Systemic Aspects of Oncogenesis (METSY)

29. 94805 Villejuif

Abstract

An automated high-resolution and sensitivity quantification of the organ and tumor distribution of fluorescent nanodiamonds injected in mice is presented.

Funder

Instituto de Salud Carlos III

European Regional Development Fund

Agence Nationale de la Recherche

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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