Cellular uptake and fate of cationic polymer-coated nanodiamonds delivering siRNA: a mechanistic study-Reference-Cited by-同舟云学术

Cellular uptake and fate of cationic polymer-coated nanodiamonds delivering siRNA: a mechanistic study

Published:2024 Issue:5 Volume:16 Page:2490-2503
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Majer Jan¹²^ORCID,Kindermann Marek²³^ORCID,Pinkas Dominik⁴^ORCID,Chvatil David⁵^ORCID,Cigler Petr²^ORCID,Libusova Lenka¹^ORCID

Affiliation:

1. Department of Cell Biology, Faculty of Science, Charles University, Vinicna 7, Prague 2, 128 00, Czechia

2. Institute of Organic Chemistry and Biochemistry of the CAS, Flemingovo namesti 2, 166 10 Prague 6, Czechia

3. Department of Physical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czechia

4. Electron Microscopy Core Facility of the Microscopy Centre, Institute of Molecular Genetics of the CAS, Videnska 1083, 142 20 Prague 4, Czechia

5. Nuclear Physics Institute of the CAS, 250 68 Husinec-Rez 130, Czechia

Abstract

Nanodiamonds coated with a random cationic copolymer based on (2-dimethylaminoethyl) methacrylate (DMAEMA) and N-(2-hydroxypropyl) methacrylamide (HPMA) enable highly effective cellular delivery of siRNAs. Clathrin-mediated endocytosis is the predominant entry mechanism.

Funder

European Regional Development Fund

Univerzita Karlova v Praze

Akademie Věd České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR05738K

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