UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor-Reference-Cited by-同舟云学术

UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor

Published:2023 Issue:7 Volume:4 Page:506-511
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Moons Sam J.¹,Hornikx Daniël L.A.H.²,Aasted Mikkel K. M.³,Pijnenborg Johan F.A.¹,Calzari Matteo¹,White Paul B.¹,Narimatsu Yoshiki³,Clausen Henrik³,Wandall Hans H.³,Boltje Thomas J.¹^ORCID,Büll Christian²³^ORCID

Affiliation:

1. Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands

2. Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands

3. Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

We report the synthesis of a photocaged sialyltransferase inhibitor that enables inducible and spatial expression of asialoglycans in human cells.

Funder

European Commission

Novo Nordisk Fonden

Lundbeckfonden

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00006K

Reference43 articles.

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