Very short highly enantioselective Grignard synthesis of 2,2-disubstituted tetrahydrofurans and tetrahydropyrans-Reference-Cited by-同舟云学术

Very short highly enantioselective Grignard synthesis of 2,2-disubstituted tetrahydrofurans and tetrahydropyrans

Published:2019 Issue:26 Volume:10 Page:6531-6538
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Monasterolo Claudio¹²³⁴⁵^ORCID,Müller-Bunz Helge¹²³⁴⁵,Gilheany Declan G.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Synthesis and Chemical Biology

2. School of Chemistry

3. University College Dublin

4. Belfield

5. Ireland

Abstract

Direct asymmetric Grignard synthesis of THFs/THPs via chiral non-racemic tertiary alcohols, applied for very short syntheses of six biological targets.

Funder

Enterprise Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00978G

Reference66 articles.

1. Asymmetric Grignard Synthesis of Tertiary Alcohols through Rational Ligand Design

2. Highly stereoselective construction of the C2 stereocentre of α-tocopherol (vitamin E) by asymmetric addition of Grignard reagents to ketones

3. Asymmetric Copper-Catalyzed Addition of Grignard Reagents to Aryl Alkyl Ketones

4. Copper(i) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones

5. Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds

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