Highly stereoselective construction of the C2 stereocentre of α-tocopherol (vitamin E) by asymmetric addition of Grignard reagents to ketones
Author:
Affiliation:
1. Centre for Synthesis and Chemical Biology
2. School of Chemistry
3. University College Dublin
4. Dublin 4
5. Ireland
Abstract
Both C2-diastereomers of α-tocopherol can be prepared in three ways by asymmetric addition of Grignard reagents to ketones in up to 96 : 4 dr.
Funder
Enterprise Ireland
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00751E
Reference64 articles.
1. One Hundred Years of Vitamins-A Success Story of the Natural Sciences
2. On the Existence of a Hitherto Unrecognized Dietary Factor Essential for Reproduction
3. Vitamin E: Emerging aspects and new directions
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