Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes-Reference-Cited by-同舟云学术

Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

Published:2016 Issue:59 Volume:52 Page:9283-9286
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Sharma Hayden A.¹²³⁴⁵,Todd Hovey M.¹²³⁴⁵,Scheidt Karl A.¹²³⁴⁵

Affiliation:

1. Department of Chemistry, Department of Pharmacology

2. Center for Molecular Innovation and Drug Discovery

3. Chemistry of Life Processes Institute

4. Northwestern University

5. Evanston

Abstract

A convergent, transition-metal-free synthesis of 2-aryl-azaindoles enabled by carbene catalysis is reported with high yields and a wide substrate scope featuring previously inaccessible azaindoles.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC04735A

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4. Synthesis and biological evaluation of 2,3-bis(het)aryl-4-azaindole derivatives as protein kinase inhibitors

5. Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

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