Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells-Reference-Cited by-同舟云学术

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

Published:2013-11-06 Issue:22 Volume:56 Page:9122-9135
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavetsias Vassilios¹,Faisal Amir¹,Crumpler Simon¹,Brown Nathan¹,Kosmopoulou Magda²,Joshi Amar³,Atrash Butrus¹,Pérez-Fuertes Yolanda¹,Schmitt Jessica A.¹,Boxall Katherine J.¹,Burke Rosemary¹,Sun Chongbo¹,Avery Sian¹,Bush Katherine¹,Henley Alan¹,Raynaud Florence I.¹,Workman Paul¹,Bayliss Richard²³,Linardopoulos Spiros¹⁴,Blagg Julian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, United Kingdom

2. Division of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom

3. Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom

4. The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401115g

Reference51 articles.

1. Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

2. Update on aurora kinase targeted therapeutics in oncology

3. The cellular geography of Aurora kinases

4. Aurora kinases in spindle assembly and chromosome segregation

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