Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies

Author:

Khan Imtiaz1234,Shah Syed Jawad Ali5674,Ejaz Syeda Abida5674,Ibrar Aliya1234,Hameed Shahid1234,Lecka Joanna89101112,Millán Jose Luis13141516,Sévigny Jean89101112,Iqbal Jamshed5674

Affiliation:

1. Department of Chemistry

2. Quaid-i-Azam University

3. Islamabad-45320

4. Pakistan

5. Centre for Advanced Drug Research

6. COMSATS Institute of Information Technology

7. Abbottabad-22060

8. Département de microbiologie-infectiologie et d'immunologie

9. Faculté de Médecine

10. Université Laval

11. Québec

12. Canada

13. Sanford Children's Health Research Center

14. Sanford-Burnham Medical Research Institute

15. La Jolla

16. USA

Abstract

The present study is directed towards the development of quinoline-4-carboxylic acid derivatives as potential alkaline phosphatase inhibitors.

Funder

Organisation for the Prohibition of Chemical Weapons

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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