Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies-Reference-Cited by-同舟云学术

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Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies

Published:2015 Issue:79 Volume:5 Page:64404-64413
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Khan Imtiaz¹²³⁴,Shah Syed Jawad Ali⁵⁶⁷⁴,Ejaz Syeda Abida⁵⁶⁷⁴,Ibrar Aliya¹²³⁴,Hameed Shahid¹²³⁴,Lecka Joanna⁸⁹¹⁰¹¹¹²,Millán Jose Luis¹³¹⁴¹⁵¹⁶,Sévigny Jean⁸⁹¹⁰¹¹¹²,Iqbal Jamshed⁵⁶⁷⁴

Affiliation:

1. Department of Chemistry

2. Quaid-i-Azam University

3. Islamabad-45320

4. Pakistan

5. Centre for Advanced Drug Research

6. COMSATS Institute of Information Technology

7. Abbottabad-22060

8. Département de microbiologie-infectiologie et d'immunologie

9. Faculté de Médecine

10. Université Laval

11. Québec

12. Canada

13. Sanford Children's Health Research Center

14. Sanford-Burnham Medical Research Institute

15. La Jolla

16. USA

Abstract

The present study is directed towards the development of quinoline-4-carboxylic acid derivatives as potential alkaline phosphatase inhibitors.

Funder

Organisation for the Prohibition of Chemical Weapons

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA12455G

Reference55 articles.

1. R. B. McComb , G. N.Bowers and S.Posen, Alkaline phosphatase, Plenum Press, New York, 1979

2. Phosphotransferase activity of human alkaline phosphatases and the role of enzyme Zn2+

3. Design and synthesis of selective inhibitors of Placental Alkaline Phosphatase

4. High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

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