High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology
Link
http://www.nature.com/articles/nprot.2010.86.pdf
Reference18 articles.
1. McComb, R.B., Bowers, G.N., Jr. & Posen, S. Alkaline Phosphatase (Plenum Press, New York, USA, 1979).
2. Millán, J.L. Mammalian Alkaline Phosphatases. From Biology to Applications in Medicine and Biotechnology (Wiley-VCH Verlag, Weinheim, Germany, 2006) pp. 1–322.
3. Millán, J.L. et al. Enzyme replacement therapy for murine hypophosphatasia. J. Bone Miner. Res. 23, 777–787 (2008).
4. Fedde, K.N. et al. Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J. Bone Miner. Res. 14, 2015–2026 (1999).
5. Whyte, M.P. et al. Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5/-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. J. Clin. Invest. 81, 1234–1239 (1988).
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