IsoquinolinequinoneN-oxides as anticancer agents effective against drug resistant cell lines-Reference-Cited by-同舟云学术

IsoquinolinequinoneN-oxides as anticancer agents effective against drug resistant cell lines

Published:2020 Issue:3 Volume:18 Page:557-568
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kruschel Ryan D.¹²³⁴⁵^ORCID,Buzid Alyah¹²³⁴⁵^ORCID,Khandavilli Udaya B. Rao¹²³⁴⁵^ORCID,Lawrence Simon E.¹²³⁴⁵^ORCID,Glennon Jeremy D.¹²³⁴⁵^ORCID,McCarthy Florence O.¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry

2. Analytical and Biological Chemistry Research Facility

3. University College Cork

4. Cork T12 K8AF

5. Ireland

Abstract

6- and 7-Substituted isoquinolineN-oxides are identified as redox active, adduct forming, anticancer agents and effective against drug resistant cell lines at nanomolar concentrations.

Funder

Irish Research Council

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02441G

Reference48 articles.

1. Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

2. Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites