Glutathione-triggered release of SO2 gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Author:

Tian Ya1,Li Pei2,Wang Likai1,Ye Xueli1,Qu Zhonghuan1,Mou Juan1,Yang Shiping1ORCID,Wu Huixia1ORCID

Affiliation:

1. The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Shanghai Frontiers Science Center of Biomimetic Catalysis, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China

2. Department of Ultrasound, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Abstract

A multifunctional nanoreactor (CCM@FH-DNs) was intelligently developed for enhancing MRI-guided chemodynamic–sonodynamic therapy through SO2 gas-augmented oxidative stress.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

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