Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide-Reference-Cited by-同舟云学术

Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide

Published:2018 Issue:26 Volume:8 Page:14597-14602
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Oliver Martin¹²³⁴,Gadais Charlène¹²³⁴,García-Pindado Júlia⁵⁶⁷⁸,Teixidó Meritxell⁵⁶⁷⁸,Lensen Nathalie¹²³⁴^ORCID,Chaume Grégory¹²³⁴^ORCID,Brigaud Thierry¹²³⁴^ORCID

Affiliation:

1. Laboratoire de Chimie Biologique (LCB)

2. Université de Cergy-Pontoise

3. 95031 Cergy-Pontoise

4. France

5. Institute for Research in Biomedicine (IRB Barcelona)

6. Barcelona Institute of Science and Technology (BIST)

7. 08028 Barcelona

8. Spain

Abstract

The incorporation of trifluoromethylated proline analogues in the tripeptide PLG enhances its hydrophobicity and promotes passive diffusion transport.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA02511H

Reference47 articles.

1. Peptide therapeutics: current status and future directions

2. The emergence of peptides in the pharmaceutical business: From exploration to exploitation

3. Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

4. Recent Advances in the Synthesis of Fluorinated Amino Acids

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