Incorporation of CF<sub>3</sub>-pseudoprolines into polyproline type II foldamers confers promising biophysical features-Reference-Cited by-同舟云学术

Incorporation of CF₃-pseudoprolines into polyproline type II foldamers confers promising biophysical features

Published:2024 Issue:65 Volume:60 Page:8609-8612
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cayrou Chloé¹²,Walrant Astrid³^ORCID,Ravault Delphine³,Guitot Karine¹²,Noinville Sylvie³,Sagan Sandrine³^ORCID,Brigaud Thierry¹²^ORCID,Gonzalez Simon¹²,Ongeri Sandrine²,Chaume Grégory¹²^ORCID

Affiliation:

1. CY Cergy Paris Université, CNRS, BioCIS UMR 8076, 95000 Cergy Pontoise, France

2. Université Paris-Saclay, CNRS, BioCIS UMR 8076, 91400 Orsay, France

3. Laboratoire des Biomolécules, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, LBM, 75005 Paris, France

Abstract

Introduction of CF3-oxazolidines in polyproline type II foldamers maintains PPII helicity, non-cytotoxicity and stability towards proteolysis. The CF3 groups enhanced hydrophobicity and are used as easy-to-handle 19F NMR probes.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02895C

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