Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate-Reference-Cited by-同舟云学术

Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate

Published:2021 Issue:11 Volume:19 Page:2448-2455
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Xuanjun¹²³⁴⁵^ORCID,McFall-Boegeman Hunter⁵⁶⁷⁸⁹,Rashidijahanabad Zahra⁵⁶⁷⁸⁹,Liu Kunli⁵⁶⁷⁸⁹,Pett Christian¹⁰¹¹¹²⁵¹³^ORCID,Yu Jin¹⁰¹¹¹²,Schorlemer Manuel¹⁰¹¹¹²⁵¹³,Ramadan Sherif⁵⁶⁷⁸⁹^ORCID,Behren Sandra¹⁰¹¹¹²⁵¹³,Westerlind Ulrika¹⁰¹¹¹²⁵¹³,Huang Xuefei⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. National Glycoengineering Research Center

2. Shandong University

3. Qingdao

4. China

5. Department of Chemistry

6. Michigan State University

7. East Lansing

8. USA

9. Institute for Quantitative Health Science and Engineering

10. Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.

11. Dortmund

12. Germany

13. Umeå University

Abstract

A MUC1 glycopeptide bearing an unnatural β-glycosyl bond between the glycan and the peptide backbone was synthesized. The mimic can induce high levels of IgG antibodies cross-recognizing cancer cells expressing the native MUC1 glycoprotein.

Funder

National Cancer Institute

Michigan Economic Development Corporation

Michigan State University Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00007A

Reference48 articles.

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