Haemoglobin(βK120C)–albumin trimer as an artificial O2carrier with sufficient haemoglobin allostery

Author:

Morita Yoshitsugu12345ORCID,Saito Asuka12345,Yamaguchi Jun12345,Komatsu Teruyuki12345ORCID

Affiliation:

1. Department of Applied Chemistry

2. Faculty of Science and Engineering

3. Chuo University

4. 1-13-27 Kasuga, Bunkyo-ku

5. Tokyo 112-8551

Abstract

Recombinant haemoglobin [rHb(βK120C)] was coupled with two human serum albumins (HSAs), yielding a rHb(βK120C)–HSA2heterotrimer, which shows a sigmoidal O2equilibrium curve and sufficient Hb allostery identical to those of native Hb.

Funder

Promotion and Mutual Aid Corporation for Private Schools of Japan

Japan Society for the Promotion of Science

Naito Foundation

Chuo University

Publisher

Royal Society of Chemistry (RSC)

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