Haemoglobin(βK120C)–albumin trimer as an artificial O2carrier with sufficient haemoglobin allostery-Reference-Cited by-同舟云学术

Haemoglobin(βK120C)–albumin trimer as an artificial O2carrier with sufficient haemoglobin allostery

Published:2020 Issue:3 Volume:1 Page:128-136
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Morita Yoshitsugu¹²³⁴⁵^ORCID,Saito Asuka¹²³⁴⁵,Yamaguchi Jun¹²³⁴⁵,Komatsu Teruyuki¹²³⁴⁵^ORCID

Affiliation:

1. Department of Applied Chemistry

2. Faculty of Science and Engineering

3. Chuo University

4. 1-13-27 Kasuga, Bunkyo-ku

5. Tokyo 112-8551

Abstract

Recombinant haemoglobin [rHb(βK120C)] was coupled with two human serum albumins (HSAs), yielding a rHb(βK120C)–HSA₂heterotrimer, which shows a sigmoidal O₂equilibrium curve and sufficient Hb allostery identical to those of native Hb.

Funder

Promotion and Mutual Aid Corporation for Private Schools of Japan

Japan Society for the Promotion of Science

Naito Foundation

Chuo University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00056F

Reference46 articles.

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3. Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism

4. The crystal structure of human deoxyhaemoglobin at 1.74 Å resolution

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