A co-formulated vaccine of irradiated cancer cells and cowpea mosaic virus improves ovarian cancer rejection

Author:

Zhao Zhongchao123ORCID,Ortega-Rivera Oscar A.1ORCID,Chung Young Hun34ORCID,Simms Andrea1,Steinmetz Nicole F.12345ORCID

Affiliation:

1. Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

2. Center for Nano-ImmunoEngineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

3. Moores Cancer Center, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

4. Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

5. Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA

Abstract

Cowpea mosaic virus adjuvants bind to irradiated cancer cells (ICCs) – the co-delivery of ICCs (the antigen) and CPMV (the adjuvant) demonstrates potent efficacy as a vaccine that protects mice from ovarian tumor challenge.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference53 articles.

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2. T.Arora , S.Mullangi and M. R.Lekkala , Ovarian cancer , StatPearls , 2022

3. Cancer statistics, 2022

4. Cancer statistics, 2020

5. Ovarian cancer standard of care: are there real alternatives?

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