3D bioprinting cowpea mosaic virus as an immunotherapy depot for ovarian cancer prevention in a preclinical mouse model

Author:

Zhao Zhongchao123ORCID,Xiang Yi1,Koellhoffer Edward C.4,Shukla Sourabh1,Fiering Steven56,Chen Shaochen1278,Steinmetz Nicole F.12347ORCID

Affiliation:

1. Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

2. Center for Nano-ImmunoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

3. Moores Cancer Center, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

4. Department of Radiology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

5. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA

6. Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA

7. Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

8. Institute for Materials Discovery and Design, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA

Abstract

Implantable bioprinted hydrogels loaded with immunostimulatory cowpea mosaic virus (CPMV) were fabricated using digital light processing (DLP) printing technology for ovarian cancer treatment.

Funder

NIH Clinical Center

National Institutes of Health

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Chemistry (miscellaneous)

Reference36 articles.

1. P. A. T. E.Board , Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treatment (PDQ®), In PDQ Cancer Information Summaries [Internet], National Cancer Institute (US), 2021

2. T.Arora , S.Mullangi and M. R.Lekkala , Ovarian cancer , StatPearls [Internet] , 2022

3. Cancer Statistics, 2021

4. Ovarian cancer standard of care: are there real alternatives?

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