Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents

Author:

Callewaert Maité12345,Roullin Valérie Gaëlle12345,Cadiou Cyril1236,Millart Elodie12345,Van Gulik Laurence78910,Andry Marie Christine12345,Portefaix Christophe111213,Hoeffel Christine111213,Laurent Sophie14151617,Elst Luce Vander1415161718,Muller Robert1415161718,Molinari Michael192021,Chuburu Françoise1236

Affiliation:

1. Institut de Chimie Moléculaire de Reims

2. CNRS UMR 7312

3. Université de Reims Champagne Ardenne

4. UFR de Pharmacie

5. 51100 Reims, France

6. 51687 Reims Cedex 2, France

7. Laboratoire de Pharmacologie

8. CNRS 3481 MEDyC

9. UFR Pharmacie

10. 51095 Reims Cedex, France

11. Service de Radiologie

12. CHU de Reims – Hôpital Maison Blanche

13. 51092 Reims Cedex, France

14. Univ. Mons

15. NMR & Mol. Imaging Lab

16. Dept Gen Organ & Biomed Chem

17. B-7000 Mons, Belgium

18. Center for Microscopy and Molecular Imaging

19. Laboratoire de Recherche en Nanosciences

20. EA4682 Université de Reims Champagne Ardenne

21. 51685 Reims Cedex 2, France

Abstract

A series of hydrogel nanoparticles incorporating MRI contrast agents (GdDOTP and MS325) as potential cross-linkers were elaborated by an easy and robust ionotropic gelation process.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference48 articles.

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