Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells-Reference-Cited by-同舟云学术

Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells

Published:2016 Issue:34 Volume:52 Page:5828-5831
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Park Hankum¹²³⁴,Koo Ja Young⁵²³⁴,Srikanth Yellamelli V. V.⁵²³⁴,Oh Sangmi⁵²³⁴,Lee Jiyoon⁶⁷²³⁴,Park Jongmin¹²³⁴,Park Seung Bum¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biophysics and Chemical Biology

2. Seoul National University

3. Seoul

4. Korea

5. Department of Chemistry

6. Mass Spectrometer Laboratory

7. National Instrument Center for Environmental Management

Abstract

The molecular shape of photoaffinity linkers significantly influences their nonspecific protein labeling of the cellular proteome.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC01426G

Reference22 articles.

1. Identification of the cellular targets of bioactive small organic molecules using affinity reagents

2. Target identification of biologically active small molecules via in situ methods

3. Target identification and mechanism of action in chemical biology and drug discovery

4. Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin

5. From noncovalent to covalent bonds: a paradigm shift in target protein identification

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