Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells-Reference-Cited by-同舟云学术

Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells

Published:2024 Issue:8 Volume:5 Page:776-786
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

McKenna Sean M.¹²,Florea Bogdan I.³^ORCID,Zisterer Daniela M.⁴,van Kasteren Sander I.³^ORCID,McGouran Joanna F.¹²^ORCID

Affiliation:

1. School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland

2. Synthesis and Solid State Pharmaceutical Centre (SSPC), Ireland

3. Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

4. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland

Abstract

A mercaptoquinoline based photo affinity probe for profiling metalloproteins was developed and applied in live cell assays, identifying several novel, therapeutically significant protein targets.

Funder

Science Foundation Ireland

Trinity College Dublin

European Molecular Biology Organization

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00053F

Reference66 articles.

1. Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

2. Flipping the Switch: Innovations in Inducible Probes for Protein Profiling

3. Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes

4. Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors

5. Proteomic profiling of metalloprotease activities with cocktails of active-site probes