DNA-compatible functional group transformations via K2RuO4-mediated oxidation-Reference-Cited by-同舟云学术

DNA-compatible functional group transformations via K₂RuO₄-mediated oxidation

Published:2024 Issue:10 Volume:11 Page:2851-2856
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

He Pengyang¹²^ORCID,Zhao Guixian¹²^ORCID,Zhu Mengping²^ORCID,Li Yangfeng²³^ORCID,Zhang Gong²³^ORCID,Li Yizhou²³^ORCID

Affiliation:

1. Chongqing University FuLing Hospital, Chongqing University, 408000 Chongqing, China

2. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, China

3. Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, 401331 Chongqing, China

Abstract

K2RuO4-mediated oxidation offers a DNA-compatible method for functional group transformations, enabling alcohol-to-carboxylic acid and amine-to-nitrile conversions valuable for DNA-encoded library synthesis.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00203B

Reference39 articles.

1. Encoded combinatorial chemistry.

2. A DNA‐Encoded Chemical Library Incorporating Elements of Natural Macrocycles

3. DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

4. Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract

5. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

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