Deep sea osmolytes in action: their effect on protein–ligand binding under high pressure stress-Reference-Cited by-同舟云学术

Deep sea osmolytes in action: their effect on protein–ligand binding under high pressure stress

Published:2022 Issue:30 Volume:24 Page:17966-17978
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Kamali Armin¹,Jahmidi-Azizi Nisrine¹,Oliva Rosario²,Winter Roland¹^ORCID

Affiliation:

1. Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Street 4a, 44227 Dortmund, Germany

2. Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126 Naples, Italy

Abstract

The deep-sea osmolytes trimethylamine-N-oxide and glycine betaine are able to modulate the ligand binding process of proflavine with serum proteins and lead to an increase in the binding constant upon pressurization.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP01769E

Reference68 articles.

1. Protein-Ligand Interactions , in Methods and Principles in Medicinal Chemistry Series , ed. H. Gohlke , Wiley-VCH , Weinheim , 2012 , vol. 53

2. Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods

3. Mechanisms of ligand binding