Water Networks Can Determine the Affinity of Ligand Binding to Proteins-Reference-Cited by-同舟云学术

Water Networks Can Determine the Affinity of Ligand Binding to Proteins

Published:2019-09-13 Issue:40 Volume:141 Page:15818-15826
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Darby John F.,Hopkins Adam P.¹,Shimizu Seishi^ORCID,Roberts Shirley M.,Brannigan James A.,Turkenburg Johan P.^ORCID,Thomas Gavin H.^ORCID,Hubbard Roderick E.²^ORCID,Fischer Marcus³^ORCID

Affiliation:

1. Demuris Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne NE4 5BX, United Kingdom

2. Vernalis (R&D) Ltd., Granta Park, Abington, Cambridge CB21 6GB, United Kingdom

3. Department of Chemical Biology & Therapeutics, and Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

Funder

Wellcome Trust

American Lebanese Syrian Associated Charities

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.9b06275

Reference54 articles.

1. A Water-Mediated and Substrate-Assisted Catalytic Mechanism for Sulfolobus solfataricus DNA Polymerase IV