Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK-Reference-Cited by-同舟云学术

Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

Published:2016 Issue:8 Volume:8 Page:821-835
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Carey Shawn P.¹²³⁴,Goldblatt Zachary E.¹²³⁴,Martin Karen E.¹²³⁴,Romero Bethsabe¹²³⁴,Williams Rebecca M.¹²³⁴,Reinhart-King Cynthia A.¹²³⁴

Affiliation:

1. Department of Biomedical Engineering

2. Cornell University

3. Ithaca

4. USA

Abstract

Fiber alignment within tumor-mimetic engineered collagen matrices drives FAK- and Rac1-dependent cellular anisotropy that promotes protrusions along fibers and suppresses off-axis protrusions to direct cell migration.

Funder

Division of Civil, Mechanical and Manufacturing Innovation

National Cancer Institute

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2016/IB/C6IB00030D

Reference68 articles.

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