Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery-Reference-Cited by-同舟云学术

Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery

Published:2024 Issue:3 Volume:12 Page:634-649
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhang Chenzhen¹^ORCID,Zhang Hengli¹^ORCID,Millán Cotto Héctor A.¹,Boyer Timothy L.¹^ORCID,Warren Matthew R.¹^ORCID,Wang Chia-Ming¹^ORCID,Luchan Joshua¹,Dhal Pradeep K.²^ORCID,Carrier Rebecca L.³,Bajpayee Ambika G.¹^ORCID

Affiliation:

1. Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA

2. Sanofi SA Global R&D, Waltham, MA, 02451, USA

3. Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA

Abstract

Surface modification of milk exosomes with hydrophilic and zwitterionic peptides improves stability in the gastrointestinal tract, permeability through intestinal mucus, and uptake into epithelial cells, thereby markedly increasing the efficiency of oral administration for gene delivery.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01089A

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