Cationic-motif-modified exosomes for mRNA delivery to retinal photoreceptors-Reference-Cited by-同舟云学术

Cationic-motif-modified exosomes for mRNA delivery to retinal photoreceptors

Published:2024 Issue:30 Volume:12 Page:7384-7400
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Millán Cotto Héctor A.¹^ORCID,Pathrikar Tanvi Vinod¹,Hakim Bill¹,Baby Helna M.¹,Zhang Hengli¹,Zhao Peng²,Ansaripour Ronak¹,Amini Rouzbeh¹³^ORCID,Carrier Rebecca L.¹²,Bajpayee Ambika G.¹²³^ORCID

Affiliation:

1. Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA

2. Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA

3. Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA

Abstract

Cationic-motif-modified exosomes provide a platform for gene delivery by overcoming ocular barriers faced during topical delivery as they exhibit full-depth penetration in porcine retinal explants significantly higher than native exosomes.

Funder

National Science Foundation

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00849A

Reference91 articles.

1. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

2. Nanomedicine and drug delivery to the retina: current status and implications for gene therapy

3. INTRAVITREAL INJECTION OF THERAPEUTIC AGENTS

4. COMPUTATIONAL SIMULATION OF ALTITUDE CHANGE-INDUCED INTRAOCULAR PRESSURE ALTERATION IN PATIENTS WITH INTRAVITREAL GAS BUBBLES

5. Patients With Intravitreal Gas Bubbles at Risk of High Intraocular Pressure Without Exceeding Elevation of Surgery: Theoretical Analysis