Can local heating and molecular crowders disintegrate amyloid aggregates?-Reference-Cited by-同舟云学术

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Can local heating and molecular crowders disintegrate amyloid aggregates?

Published:2024 Issue:16 Volume:15 Page:6095-6105
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kumar Naresh¹^ORCID,Khatua Prabir²,Sinha Sudipta Kumar¹^ORCID

Affiliation:

1. Department of Chemistry, Theoretical and Computational Biophysical Chemistry Group, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India

2. Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Bengaluru 562163, India

Abstract

The present study employs a blend of molecular dynamics simulations and a theoretical model to explore the potential disintegration mechanism of a matured Aβ octamer, aiming to offer a strategy to combat Alzheimer's disease.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00103F

Reference50 articles.

1. Has the Amyloid Cascade Hypothesis for Alzheimers Disease been Proved?

2. Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

3. Alzheimer's Disease: Genes, Proteins, and Therapy

4. The role of amyloid β peptide 42 in Alzheimer's disease

5. Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

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