A divergent synthetic pathway for pyrimidine-embedded medium-sized azacycles through an N-quaternizing strategy
Author:
Affiliation:
1. CRI Center for Chemical Proteomics
2. Department of Chemistry
3. Seoul National University
4. Seoul 08826
5. Korea
Abstract
A new divergent synthetic pathway for skeletally distinct pyrimidine-containing medium-sized azacycles was developed. Diversity-generating reactions via selective bond cleavages or migrations from N-quaternized intermediates were designed, and 14 discrete core skeletons were synthesized in an efficient manner. The skeletal diversity of the resulting molecular frameworks was confirmed by chemoinformatic analysis.
Funder
National Research Foundation of Korea
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC04061C
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