Tailoring of novel morpholine-sulphonamide linked thiazole moieties as dual targeting DHFR/DNA gyrase inhibitors: synthesis, antimicrobial and antibiofilm activities, and DFT with molecular modelling studies-Reference-Cited by-同舟云学术

Tailoring of novel morpholine-sulphonamide linked thiazole moieties as dual targeting DHFR/DNA gyrase inhibitors: synthesis, antimicrobial and antibiofilm activities, and DFT with molecular modelling studies

Published:2024 Issue:20 Volume:48 Page:9149-9162
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Abdou Moaz M.¹^ORCID,Eliwa Essam M.²,Abdel Reheim M. A. M.³,Abu-Rayyan Ahmed⁴,Abd El-Gilil Shimaa M.⁵,Abu-Elghait Mohammed⁶,Sharaf Mohamed H.⁶,Kalaba Mohamed H.⁶,Halawa Ahmed H.²,Elgammal Walid E.²^ORCID

Affiliation:

1. Egyptian Petroleum Research Institute, Nasr City, Cairo, 11727, Egypt

2. Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt

3. Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

4. Faculty of Science, Applied Science Private University, Amman, 11931, Jordan

5. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11754, Egypt

6. Department of Botany and Microbiology, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt

Abstract

Herein, the chemical synthesis of new thiazole-based benzenesulfonamide-linked morpholine 4a,b–7via late-stage thiazolation of the corresponding thiosemicarbazone 3 is reported.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D3NJ05774G

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5. Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening