The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors-Reference-Cited by-同舟云学术

The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors

Published:2021 Issue:31 Volume:45 Page:13986-14004
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

El-Shershaby Mohamed H.¹²³⁴⁵^ORCID,El-Gamal Kamal M.¹²³⁴⁵,Bayoumi Ashraf H.¹²³⁴⁵,El-Adl Khaled⁶²³⁷⁵^ORCID,Alswah Mohamed¹²³⁴⁵,Ahmed Hany E. A.¹²³⁴⁵^ORCID,Al-Karmalamy Ahmed A.⁸²⁹¹⁰⁵^ORCID,Abulkhair Hamada S.¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department

2. Faculty of Pharmacy

3. Al-Azhar University

4. Nasr City 11884

5. Egypt

6. Department of Medicinal Chemistry & Drug Design

7. Cairo

8. Pharmaceutical Chemistry Department

9. Horus University - Egypt

10. New Damietta

Abstract

The resistance of pathogenic microbes to currently available antimicrobial agents has been considered a global alarming concern.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02838C

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4. Methicillin and vancomycin resistant S. aureus in hospitalized patients

5. DNA topoisomerase II, genotoxicity, and cancer

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