The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors-Reference-Cited by-同舟云学术

The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors

Published:2021 Issue:31 Volume:45 Page:13986-14004
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

El-Shershaby Mohamed H.¹²³⁴⁵^ORCID,El-Gamal Kamal M.¹²³⁴⁵,Bayoumi Ashraf H.¹²³⁴⁵,El-Adl Khaled⁶²³⁷⁵^ORCID,Alswah Mohamed¹²³⁴⁵,Ahmed Hany E. A.¹²³⁴⁵^ORCID,Al-Karmalamy Ahmed A.⁸²⁹¹⁰⁵^ORCID,Abulkhair Hamada S.¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department

2. Faculty of Pharmacy

3. Al-Azhar University

4. Nasr City 11884

5. Egypt

6. Department of Medicinal Chemistry & Drug Design

7. Cairo

8. Pharmaceutical Chemistry Department

9. Horus University - Egypt

10. New Damietta

Abstract

The resistance of pathogenic microbes to currently available antimicrobial agents has been considered a global alarming concern.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02838C

Reference77 articles.

1. Antibiotic resistant bacteria and commensal fungi are common and conserved in the mosquito microbiome

2. An overview of the antimicrobial resistance mechanisms of bacteria

3. The World Health Organization, Antimicrobial resistance, https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance , (accessed 27 April 2021)

4. Methicillin and vancomycin resistant S. aureus in hospitalized patients

5. DNA topoisomerase II, genotoxicity, and cancer

Cited by 52 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Harnessing molecular hybridization approach to discover novel quinoline EGFR-TK inhibitors for cancer treatment;Future Medicinal Chemistry;2024-05-09

2. Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties;BMC Chemistry;2024-02-16

3. Dihydrofolate Reductase (DHFR) Inhibitors: A Comprehensive Review;Current Medicinal Chemistry;2024-02

4. Effective Microwave-Assisted Synthesis of 2-Chloro-5,6-dimethyl-3-(((substituted-benzylidene)hydrazono)methyl)-quinoline and Its Biological Assessment;Russian Journal of Bioorganic Chemistry;2024-02

5. Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers;RSC Advances;2024