Markov state models and NMR uncover an overlooked allosteric loop in p53
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. University of California San Diego
3. USA
4. Department of Pharmaceutical Sciences
5. University of California Irvine
6. Irvine
7. Department of Molecular Biology and Biochemistry
Abstract
Wildtype and Y220C L1 and L6 loops conformational landscape, with MSM-identified L6 states highlighted on the right.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05053A
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