Oncogenic R248W mutation induced conformational perturbation of the p53 core domain and the structural protection by proteomimetic amyloid inhibitor ADH-6

Author:

Liu Qian1,Yu Yawei1,Wei Guanghong1ORCID

Affiliation:

1. Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China

Abstract

Oncogenic R248W mutation of p53C induces a shift of helix H2 and β-hairpin S2–S2′ towards the mutation site, destabilizing the β-sheet. ADH-6 inhibits this shift and stabilizes p53C by binding to the mutation site and multiple destabilized regions.

Funder

Natural Science Foundation of Shanghai Municipality

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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