Oncogenic R248W mutation induced conformational perturbation of the p53 core domain and the structural protection by proteomimetic amyloid inhibitor ADH-6

Abstract

Oncogenic R248W mutation of p53C induces a shift of helix H2 and β-hairpin S2–S2′ towards the mutation site, destabilizing the β-sheet. ADH-6 inhibits this shift and stabilizes p53C by binding to the mutation site and multiple destabilized regions.