Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophile-Reference-Cited by-同舟云学术

Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophile

Published:2016 Issue:5 Volume:7 Page:864-872
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Dahal Upendra P.¹²³⁴⁵,Gilbert Adam M.⁶³⁴⁵,Obach R. Scott¹²³⁴⁵,Flanagan Mark E.⁶³⁴⁵,Chen Jinshan M.⁶³⁴⁵,Garcia-Irizarry Carmen⁶³⁴⁵,Starr Jeremy T.⁶³⁴⁵,Schuff Brandon⁶³⁴⁵,Uccello Daniel P.⁶³⁴⁵,Young Jennifer A.⁶³⁴⁵

Affiliation:

1. Pharmacokinetics

2. Dynamics and Metabolism

3. Pfizer Worldwide Research and Development

4. Groton

5. USA

6. Worldwide Medicinal Chemistry

Abstract

Covalent drugs contain a reactive electrophilic moiety or covalent reactive group (CRG), which forms an irreversible bond between the drug and a biological target.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00017G

Reference29 articles.

1. The resurgence of covalent drugs

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4. Involvement of the Immune System in Idiosyncratic Drug Reactions

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