Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom <i>via</i> Rh(<scp>iii</scp>)-catalyzed CF<sub>3</sub>-carbenoid C–H functionalization and defluorinative annulation-Reference-Cited by-同舟云学术

Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom via Rh(iii)-catalyzed CF₃-carbenoid C–H functionalization and defluorinative annulation

Published:2023 Issue:6 Volume:10 Page:1544-1550
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Haosheng¹,Mei Mingjing²,Wang Duozhi¹^ORCID,Zhou Lei¹²^ORCID

Affiliation:

1. State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi, 830046, Xinjiang, P. R. China

2. School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China

Abstract

A Rh-catalyzed two-fold C–F bond cleavage enabled [4 + 2] annulation reaction via CF3-carbenoid C–H functionalization of arenes with indoles or various classes of azoles as the directing groups was developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO02008D

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