Fluorination methods in drug discovery
Author:
Affiliation:
1. Departamento de Química Orgánica
2. Facultad de Farmacia y Bioquímica
3. Universidad de Buenos Aires-CONICET
4. 1113-Buenos Aires
5. Argentina
6. CIHIDECAR-CONICET
7. Pabellón II
8. 3er piso
9. Ciudad Universitaria
Abstract
Late stage fluorination methods applied to biologically-active drugs have provided the pharmaceutical industry with new leads that show improved properties such as modulation of lipophilicity, electronegativity, basicity, bioavailability, and deceleration of metabolic degradation.
Funder
Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00764C
Reference212 articles.
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2. Organofluorine chemistry: applications, sources and sustainability
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4. Applications of Fluorine in Medicinal Chemistry
5. Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights
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