Alkyl triphenylphosphonium surfactants as nucleic acid carriers: complexation efficacy toward DNA decamers, interaction with lipid bilayers and cytotoxicity studies

Author:

Zakharova Lucia Ya.1234ORCID,Kaupova Guzalia I.564,Gabdrakhmanov Dinar R.1234,Gaynanova Gulnara A.1234,Ermakova Elena A.7284,Mukhitov Alexander R.7284,Galkina Irina V.9104,Cheresiz Sergey V.11124,Pokrovsky Andrey G.11124,Skvortsova Polina V.7284,Gogolev Yuri V.7284,Zuev Yuriy F.7284ORCID

Affiliation:

1. A.E. Arbuzov Institute of Organic and Physical Chemistry

2. FRC Kazan Scientific Center of RAS

3. Kazan 420088

4. Russia

5. Scientific and Technological Center of PAO “Niznekamskneftekhim”

6. Nizhnekamsk 423574

7. Kazan Institute of Biochemistry and Biophysics

8. Kazan 420111

9. Kazan (Volga Region) Federal University

10. Kazan 420008

11. Novosibirsk State University

12. Novosibirsk 630090

Abstract

Herein, for the first time the complexation ability of a homological series of triphenylphosphonium surfactants (TPPB-n) toward DNA decamers has been explored.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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