Unravelling the effect ofN(ε)-(carboxyethyl)lysine on the conformation, dynamics and aggregation propensity of α-synuclein-Reference-Cited by-同舟云学术

Unravelling the effect ofN(ε)-(carboxyethyl)lysine on the conformation, dynamics and aggregation propensity of α-synuclein

Published:2020 Issue:12 Volume:11 Page:3332-3344
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mariño Laura¹²³⁴⁵^ORCID,Ramis Rafael¹²³⁴⁵^ORCID,Casasnovas Rodrigo¹²³⁴⁵^ORCID,Ortega-Castro Joaquín¹²³⁴⁵^ORCID,Vilanova Bartolomé¹²³⁴⁵^ORCID,Frau Juan¹²³⁴⁵^ORCID,Adrover Miquel¹²³⁴⁵^ORCID

Affiliation:

1. Institut Universitari d'Investigació en Ciències de la Salut (IUNICS)

2. Institut d’Investigació Sanitària Illes Balears (IdISBa)

3. Departament de Química

4. Universitat de les Illes Balears

5. E-07122 Palma de Mallorca

Abstract

We study the effect of an advanced glycation end product (N(ε)-(carboxyethyl)lysine), found on the Lewy bodies of people suffering from Parkinson’s disease, on the conformational and aggregation features of alpha-synuclein.

Funder

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC00906G

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