Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments-Reference-Cited by-同舟云学术

Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments

Published:2024 Issue:13 Volume:22 Page:2670-2676
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bosbach Clara¹²,Gatzemeier Luisa Maria¹²,Bloch von Blottnitz Katja Ilme¹,König Annekatrin²,Diederichsen Ulf¹,Steinem Claudia¹^ORCID,Outeiro Tiago Fleming²³⁴^ORCID

Affiliation:

1. Institute of Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Tammannstraße 2, 37077 Göttingen, Germany

2. Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Waldweg 33, 37073 Göttingen, Germany

3. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK

4. Max Planck Institute for Multidisciplinary Sciences, Hermann-Rein-Straße 3, 37075 Göttingen, Germany

Abstract

A strategy for multiple site-selective glycation of lysine side chains was developed, enabling the creation of glycated α-synuclein fragments implicated in neuronal dysfunction.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00225C

Reference56 articles.

1. Current Trends in the Analysis of Post-translational Modifications

2. Post-translational modifications: Regulators of neurodegenerative proteinopathies

3. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

4. Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein

5. The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

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