Incorporation of aerobic oxygen into the hydroxyglycyl intermediate during formation of C-terminal peptide amides by peptidylglycine α-amidating monooxygenase (PAM)-Reference-Cited by-同舟云学术

Incorporation of aerobic oxygen into the hydroxyglycyl intermediate during formation of C-terminal peptide amides by peptidylglycine α-amidating monooxygenase (PAM)

Published:1991 Issue:8 Volume: Page:571-572
ISSN:0022-4936
Container-title:J. Chem. Soc., Chem. Commun.
language:en
Short-container-title:J. Chem. Soc., Chem. Commun.

Author:

Zabriskie T. Mark,Cheng Hengmiao,Vederas John C.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/1991/C3/C39910000571

Reference14 articles.

1. Biosynthesis of the C-terminal amide in peptide hormones

2. Peptide α-Amidation

3. The reaction product of peptidylglycine alpha-amidating enzyme is a hydroxyl derivative at alpha-carbon of the carboxyl-terminal glycine.

4. A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of .alpha.-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine .alpha.-amidating monooxygenase in peptide amidation

5. Novel substrates and inhibitors of peptidylglycine .alpha.-amidating monooxygenase

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1. Enzymes Involved in Redox Reactions: Natural Sources and Mechanistic Overview;Redox Biocatalysis;2012-09-24

2. Involvement of Metals in Enzymatic and Nonenzymatic Decomposition of C-Terminal α-Hydroxyglycine to Amide: An Implication for the Catalytic Role of Enzyme-Bound Zinc in the Peptidylamidoglycolate Lyase Reaction;Biochemistry;2009-01-26

3. Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM);Bioorganic & Medicinal Chemistry;2008-12

4. The Catalytic Role of the Copper Ligand H172 of Peptidylglycine α-Hydroxylating Monooxygenase (PHM): A Spectroscopic Study of the H172A Mutant;Biochemistry;2002-10-10

5. Selective α-Carbon Hydroxylation of Glycine in Nickel(II)–Cyclotetrapeptide Complexes by Oxygen Metal complexes of biologically important ligands, Part 144. For Part 143 see: J. Schapp, W. Beck, Z. Naturforsch. 2002, 576, 280–284. This work was supported by the Deutsche Forschungsgemeinschaft and Fonds der Chemischen Industrie. We thank Professor Bernard Meunier, Tolouse, for a very valuable comment.;Angewandte Chemie International Edition;2002-06-03