Enhanced binding of methyl alkylammonium cations through preorganization of a water-soluble calix[4]pyrrole-Reference-Cited by-同舟云学术

Enhanced binding of methyl alkylammonium cations through preorganization of a water-soluble calix[4]pyrrole

Published:2024 Issue:28 Volume:22 Page:5827-5834
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Valencia Esteban¹²^ORCID,Ballester Pablo¹³^ORCID

Affiliation:

1. Institute of Chemical Research of Catalonia (ICIQ)-CERCA, The Barcelona Institute of Science and Technology (BIST), Av. Països Catalans 16, 43007 Tarragona, Spain

2. Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili (URV), c/Marcel·lí Domingo 1, 43007 Tarragona, Spain

3. ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain

Abstract

The binding of pyridine-N-oxide with a calix[4]pyrrole results in the self-assembly of a preorganized supramolecular receptor displaying significant affinity (log K = 3–4) for the binding of tetra-alkylammonium cations in water.

Funder

Ministerio de Ciencia e Innovación

Generalitat de Catalunya

Agència de Gestió d’Ajuts Universitaris i de Recerca

Institut Català d'Investigació Química

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00843J

Reference41 articles.

1. Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

2. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

3. Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

4. The Cation−π Interaction at Protein–Protein Interaction Interfaces: Developing and Learning from Synthetic Mimics of Proteins That Bind Methylated Lysines

5. The Cation−π Interaction