The irony of chirality – unveiling the distinct mechanistic binding and activities of 1-(3-(4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)prop-2-en-1-one enantiomers as irreversible covalent FGFR4 inhibitors
Author:
Affiliation:
1. Molecular Bio-computation and Drug Design Laboratory
2. School of Health Sciences
3. University of KwaZulu-Natal
4. Durban 4001
5. South Africa
Abstract
Theoretical investigation of the effect of chirality on inhibitors is providing essential insights for drug design.
Funder
Inyuvesi Yakwazulu-Natali
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02811G
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